Macroporous hydrogel scaffolds with tunable physicochemical properties for tissue engineering constructed using renewable polysaccharides - Research Progress

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Macroporous hydrogel scaffolds with tunable physicochemical properties for tissue engineering constructed using renewable polysaccharides

2020-04-09

Polysaccharide-based hydrogels exhibit unique properties like renewability, biocompatibility and biodegradability, thus making them ideal materials for potential utility in tissue engineering scaffolds, drug delivery vehicles, and water purification devices. Salecan, a water-soluble b-1,3-glucan secreted by the Agrobacterium sp. ZX09, has become a vital family of polysaccharides for the construction of hydrogels owing to its biofunctionality and susceptibility to chemical modification. In the past few years, research on developing functional salecan polysaccharide-based hydrogels has been one of the focus of our group, which can be divided into the following two parts:

1. Previous studies to design polysaccharide-based hydrogels for separation devices (ACS Sustainable Chemistry & Engineering, 2019; Carbohydrate Polymers, 2019; International Journal of Biological Macromolecules, 2020, 145, 1049–1058; Carbohydrate Polymers, 2019, 209, 101–110).

2. Designing polysaccharide-based hydrogel scaffolds for tissue engineering (ACS Applied Materials & Interfaces, 2020, Back Cover; Carbohydrate Polymers, 2020; Journal of Agricultural and Food Chemistry, 2020, Back Cover; Carbohydrate Polymers, 2019, 224, 115208).

These works was financially supported by the National Natural Science Foundation of China (31800833 and 21977081), Zhejiang Provincial Natural Science of Foundation of China (Z19H180001), the Wenzhou Medical University and Wenzhou Institute of Biomaterials & Engineering (WIBEZD2017001-03).