Fig. 1. In vitro anti-biofilms effect of D/L-Glu- Au NBPs.

Fig. 2. In vivo antibacterial activity of D/L-Glu-Au NBPs.

Here, Yunlong Zhou’ research group (Wenzhou Institute, University of Chinese Academy of Sciences) and professor Bailiang Wang constructed a chiral glutamic acid functionalized gold nanobipyramids (Au NBPs) for enhanced PTT against bacterial and biofilms infections. Specifically, the conjugation of D/L-glutamic acid (D/L-Glu) obviously enhanced the targeting and interactions of Au NBPs with bacterial cell wall leading to the biological restriction of nucleic acids. Both in vitro(Fig.1.) and in vivo（Fig.2.）, antibacterial and anti-biofilms measurements verified high efficiency in killing of bacteria and eliminating of biofilms through a synergistic chemotherapy, physiotherapy and PTT functions. Furthermore, the quick targeting of chiral Au NBPs to the bacteria and penetrating into extracellular matrix effectively avoided the nonspecific damage to normal cells. The journal publication (Synergistic chemotherapy, physiotherapy and photothermal therapy against bacterial and biofilms infections through construction of chiral glutamic acid functionalized gold nanobipyramids) was published in Chemical Engineering Journal（IF：8.355）. The first author was Min Zhang, the graduate student of research group.

Link：https://doi.org/10.1016/j.cej.2020.124778