Periodontitis could not only compromise life qualities sharply, but also hazard the systematic fitness due to bacterial-related factors. In this study, the facile engineering of a functional hydrogel carrier composed of curdlan polysaccharide and polydopamine (PDA) was reported for periodontal treatment. The physiochemical evaluations of curdlan and PDA composite hydrogel (CP) proved its competent properties associated with concentration of PDA. We have systematically assessed the designed hydrogels for the biocompatible experiments in vitro and found that these hydrogels exhibited good cytocompatibility. Moreover, photothermal performance upon near infrared light (NIR) exposure was conducted and eventually indicated the best matches for antibacterial application (CP3). The acetate chlorhexidine (CHX) was chosen as a model antimicrobial and the drug release profiles demonstrated that the triggered release of entrapped CHX could be nicely controlled by NIR. The optimized bacteriostatic rate could reach 99.9%. Overall, we aimed to provide a new alternative synergistic antibacterial strategy for periodontal treatment by combining photothermal effect and chemical antimicrobial simultaneously. This work was published in the Carbohydrate Polymers (IF：6.044)

Nanotechnology and nanomaterials serving as short interfering RNA (siRNA) delivery systems have flourished since RNA interference (RNAi) technology was shown to be an effective tool for fighting various diseases via gene silencing siRNAs are typically short double-stranded RNA molecules with about 19 base pairs (bp) in their core region This unique molecular structure may allow siRNAs to act as rigid building blocks for bottom-up fabrication of nanostructures beyond their genetic role In fact, rigid DNA crossovers have been extensively exploited for the preparation of well-defined nanostructures Moreover, the rigidity of DNA has been thoroughly investigated in the last few years Although self-assembly of siRNA was extensively investigated, there is still no report highlighting the molecular rigidity of siRNA in its self-assembly behavior Herein, polymerization-induced electrostatic self-assembly (PIESA) is conducted to mediate the self-assembly behavior of short interfering RNA (siRNA) for the first time

Polysaccharides have recently attracted increasing attention in the construction of hydrogel devices for biomedical

Shen and Chen group from Wenzhou Medical University have summarized functional magnetic iron oxide nanoparticles (Fe3O4 NPs) have shown great potential as an advanced platform because of their inherent magnetic resonance imaging (MRI), biocatalytic activity (nanozyme), magnetic hyperthermia treatment (MHT), photo-responsive therapy and drug delivery for chemotherapy and gene therapy.