Shen's Group

Jianliang Shen, B.Eng., M.S., Ph.D.
Principal Investigator
Wenzhou Institute, University of Chinese Academy of Sciences;
State Key Laboratory of Ophthalmology, Optometry and Vision Science;
Wenzhou Medical University
No.16 Xinsan Road, Hi-tech Industry Park, Wenzhou, China
Tel: (+86)-131-5737-2733
Email: shenjl@wiucas.ac.cn

General Information
Date of Birth: Nov.17^th1984
Sex: Male
Marital Status: Married

Education
9/2010 – 5/2014   Ph.D., SunYat-Sen University (PI: Prof. Zongwan Mao)
9/2007 – 7/2010   M.S., Xiangtan University (PI: Prof. Lifeng Tan)
9/2003 – 7/2007   B.Eng., Hunan University of Science & Technology

Working Experience
9/2017 – Present   Professor, Wenzhou Medical University
9/2017 – Present   Professor, Wenzhou Institute，University of Chinese Academy of Sciences
6/2014 – 6/2017   Postdoctoral Fellow, Houston Methodist Research Institute (PI: Prof. Haifa Shen)
6/2012 – 4/2014   Research Fellow, Houston Methodist Research Institute (PI: Prof. Haifa Shen)

Research Interests and Backgrounds
I am a biologist and material scientist with a strong interest in applying micro/nano-technology platforms for cancer and other diseases drug discovery. My overall research interest is on precision medicine for human cancers, such as (1) an injectable nanoparticle generator platform for targeted delivery and in situ activation of prodrugs at the tumor lesion, (2) an inflammatory tumor vasculature-targeted delivery system for small molecule inhibitors and therapeutic siRNA, and (3) a highly potent therapeutic cancer nano-vaccine platform. A biomaterial and nanomedicine doctor by training, I have acquired strong experience in biomaterials during past years (Theranostics 2014, ACS Nano 2013, Advanced Healthcare Materials 2014, Nanoscale 2017), cancer genetics through postdoctoral training (Nature Biotechnology 2016, Materials Today 2017, Nano Letters 2017, Nanoscale 2017), and functional materials applied on medicine (Chemical Society Reviews 2018, Biomaterials 2018, Theranostics 2018, Clinical Cancer Research 2018, 2018). I have also ained extensive experience on cancer drug development with 10 years in the university and academic institute on development of novel cancer drugs. My current research is focused on development of therapeutics and technologies to advance cancer metastasis, tissue engineering, antibacterial materials and medical probes and so on. I strongly believe that different diseases should be treated differently based on their unique microenvironments and transport properties, and that nanotechnology offers a unique advantage on drug delivery to most of the illness. Recently, our studies have demonstrated that we now have powerful biomaterial systems to overcome biological barriers and effectively deliver therapeutics to such diseases (Iscience 2019, Bioactive Materials 2021, 2021, Advanced Science 2022, 2022, Chemical Engineering Journal 2021, 2022).

Selected Publications

1. He, X., Dai, L., Ye, L., Sun, X., Enoch, O., Hu, R., Zan, X., Lin, F., Shen, J.. A Vehicle‐Free Antimicrobial Polymer Hybrid Gold Nanoparticle as Synergistically Therapeutic Platforms for Staphylococcus Aureus Infected Wound Healing, Advanced Science, 2022, 9, 2105223. (IF: 17.524)

2. Qi, X., Huang, Y., You, S., Xiang, Y., Cai, E., Mao, R., Pan, W., Tong, X., Dong, W., Ye, F., Shen, J.. Engineering Robust Ag‐Decorated Polydopamine Nano‐Photothermal Platforms to Combat Bacterial Infection and Prompt Wound Healing, Advanced Science, 2022, 9, 2106015. (IF: 17.524)

3.He, X., Hou, J., Sun, X., Jangili, P., An, J., Qian, Y., Kim, J. M., Shen, J.. NIR‐II Photo‐Amplified Sonodynamic Therapy Using Sodium Molybdenum Bronze Nanoplatform against Subcutaneous Staphylococcus Aureus Infection, Advanced Functional Materials, 2022, 2203964. (IF: 19.924)

4.Qian, Y., Zheng, Y., Jin, J., Wu, X., Xu, K., Dai, M., Niu, Q., Zheng, H., He, X., Shen, J.. Immunoregulation in Diabetic Wound Repair with a Photo‐Enhanced Glycyrrhizic Acid Hydrogel Scaffold, Advanced Materials, 2022**, 34, 2200521. (IF: 32.086)

5. Liu, Y., Zhou, Z., Hou, J., Xiong, W., Kim, H., Chen, J., Zheng, C., Jiang, X., Yoon, J., Shen, J.. Tumor Selective Metabolic Reprogramming as a Prospective PD-L1 Depression Strategy to Reactivate Immunotherapy, Advanced Materials*, 2022**, e2206121. doi: 10.1002/adma.202206121. (IF: 32.086)

6. Li, Z., Hou, J., Wang, S., Zhu, L., He, X., Shen, J.. Recent Advances of Luminescent Sensors for Iron and Copper: Platforms, Mechanisms, and Bio-applications, Coordination Chemistry Reviews, 2022, 469,2146995. (IF: 24.833)

7.Hou, J., Kwon, N., Wang, S., Wang, B., He, X., Yoon, J., Shen, J.. Sulfur-based Fluorescent Probes for HOCl: Mechanisms, Design, and Applications, Coordination Chemistry Reviews, 2022, 450, 214232. (IF: 24.833)

8. Qi, X., Xiang, Y., Cai, E., You, S., Gao, T., Lan, Y., Deng, H., Li, Z., Hu, R., Shen, J.. All-in-one: Harnessing Multifunctional Injectable Natural Hydrogels for Ordered Therapy of Bacteria-infected Diabetic Wounds, Chemical Engineering Journal, 2022, 439, 135691. (IF: 16.744)

9. Zeng, Q., Qian, Y., Huang, Y., Ding, F., Qi, X., Shen, J.. Polydopamine Nanoparticle-Dotted Food Gum Hydrogel with Excellent Antibacterial Activity and Rapid Shape Adaptability for Accelerating Bacteria-Infected Wound Healing, Bioactive Materials, 2021. (IF=16.874, ESI 0.1%)

10. Su, T., Zhang, M., Pan, W., Qian, Y., Zhou, Z., He, X., Shen, L., Dong, W., Qi, X., Shen, J.. Mussel-inspired Agarose Hydrogel Scaffolds for Skin Tissue Engineering. Bioactive Materials*, 2021. (IF=16.874, ESI 1%)