Yuru DENG's Research Group


Group Name

Biological Cubic Membrane Research Group

Principal Investigator

Dr. Yuru DENG
Wenzhou institute, UCAS
Email: dengyr@ucas.ac.cn

Biography

Research Interests

Formation mechanism, three-dimensional nanostructure, optical and antioxidant properties and application of biological cubic membrane (BCM).
Application of BCM in gene, protein and drug encapsulation.
Extraction, chemical and biosynthesis of natural substances derived from phospholipid by cubic membrane and its role in the pathogenesis, prevention and treatment in Alzheimer's disease (AD).

Dr. Yuru Deng’s Lab of Biological Cubic Membrane Research

We use perspectives from biology, chemistry and biophysical chemistry to understand the application of new gene protein carriers, 3D structure and optical properties of cubic membrane (CM), and antioxidant properties of phospholipids. It is our interest to investigate the microglial ultrastructure on purpose of cubic membrane initiation by starvation stress and other stresses. Recently, plasmalogen and other phospholipids become an attractive part of modern research to aid the AD patients as it is found that plasmalogen becomes less in the brain of AD patients. So, we are trying to know the role and mechanism of plasmalogen and at the same time we are focusing on the industrialization of plasmalogen production commercially. Please see our ‘Research Projects’ section for some specific projects we are working on and how you can get involved!

Research Projects

Research Article

Bicontinuous cubic phases in biological and artificial self-assembled systems, Science China Materials, 2020, 10.1007/s40843-019-1261-1

Summary

Bicontinuous cubic structures are one of the complex biological structures, which are often described by triply periodic minimal surfaces (TPMSs) and their constant mean curvature (CMC)/parallel surface companions, unique physical properties are of special interest to various research fields. In this article, the formation mechanism and relationships of relevant biological and artificial self-assembly are discussed and summarized. These structures can be formed through biological processes with regulation across corresponding to the molecular size and curvature. The block copolymeric system is considered to be an attractive model for the study of biological systems. Here, some of the phenomena found in these two systems are compared and discussed, and this information may provide new ideas to understand the relationship between molecular shape and resulting interface curvature and the self-assembly process in living organisms.

Initiative Works


Conference on Plasmalogen co-sponsored by Shanghai Jiaotong University, Zhejiang University, Wenzhou Institute, UCAS and Institute of Physics, CAS


Research Center for Plasmalogen


1st International Mini-Symposium, hosted by Wenzhou Institute, UCAS, 2019.11.07-11.09


Topic Editor of Special Issue

Representative Publications