Huaqiong LI's Research Group

Group Name

Xeno-Biomaterials Research Group

Principal Investigator

Dr. Huaqiong LI
Wenzhou Institute
Heterogeneous tissue repair material is a potential implant material. Hyperacute rejection (HAR) will happen when transferring porcine tissues into primates, which is caused by α1, 3-galactose (α1, 3 Gal). The enzyme α1, 3-galactosyltransferase (α1, 3 GT) synthesizes α1, 3 Gal epitopes on the cell surface. In order to avoid the occurrence of immune rejection, the experimental materials selected by our group are from α - 1,3-galactosidase (GGTA1) gene knockout pigs, which can reduce the rejection between the implant and the host as much as possible. In addition, using the principles and methods of tissue engineering to construct the graft, provides a new idea and method for the repair of tissue defects. In our research group, we combined the acellular matrix and polymer to construct bone, cartilage and tympanic membrane repair tissue engineering scaffolds with excellent mechanical properties and cellular biological properties by 3D printing and other technologies. The structure and performance of scaffolds are used to control the in situ growth of cells and the entry and maintenance of specific types of development pathway of cells around the defect site in vivo, and finally to form healthy tissue with morphology and function.
At present, there are 3 PhDs, 2 Research Assistants and 3 postgraduate students in the research group. Dr. Li Huaqiong, leader of the research group, was selected into the China-Australia Young Scientist Exchange Program of the Ministry of Science and Technology in 2019 and the 580 Overseas Elite Program of Wenzhou City. He has published more than 20 SCI papers in biomaterials related journals (such as ACS Applied Materials and Interfaces, Acta Biomaterialia, Chemical Engineering Journal, Journal of Materials Chemistry B, etc.). After joining the Institute in 2015, he has granted five projects at the national, provincial and municipal levels (with a total of more than 5 million). He has applied for 6 patents (with one authorized). He was also supported by the exchange program of the Ninth Regular Session of the China-Croatia Science and Technology Cooperation Commission of the Ministry of Science and Technology.

Research Progress

1、Dr Huaqiong Li just published a Acta Biomaterialia paper on 4D printing. Congratulations on publishing an important review article in the field.
In this review, the state-of-the-art efforts in integrating the time-dependent behaviour of stimulus-responsive materials in 4D printing will be discussed. In addition, we have demonstrated the significance of 4D printing in biomedical applications, in which “time” has been incorporated into the conventional concept of 3D printing as the 4th dimension. As such, 4D printing differentiates and evolves from 3D printing using stimulus-responsive materials which can actively respond to external stimuli and more sophisticated “hardware”-printer which can achieve multi-printing via mathematical-predicted designs that are programmed to consider the transformation of 3D constructs over time. The emphasize will be on the interactions between various types of stimuli with the associated stimulus-responsive materials, followed by technical considerations as well as outlook for future discoveries.
2、Dr Huaqiong Li and Dr Yunyun Quan just published a Chemical Engineering Journal paper on superhydrophobic composite materials. Congratulations on publishing an important article in the field.
In this paper, a facile one-pot synthesis method was reported to fabricate multifunctional superhydrophobic composite materials with remarkable mechanochemical robustness, stain repellency, oilwater separation and sound-absorption. Their mechanical and chemical durability could be greatly improved by chemically adhering epoxy resin microspheres (ERMs) on 3-D porous skeleton structures of latex sponge. The materials could retain superhydrophobicity after going through sandpaper abrasion, ultrasonication, multiple knife scratch, tape peeling and fnger wiping, and exposure to UV irradiation and high temperature. The materials are able to maintain the repellency against strong acid and alkali.