摘要： Bioresponsive MRI probes based on paramagnetic complexes can substantially improve the outcome of functional molecular imaging studies. They alter the MR image contrast in response to changes in the local environment and thus serve as valuable functional markers, providing outst anding specificity at molecular and cellular level. We have developed different types of paramagnetic and biocompatible bioresponsive MRI probes over the past several years. They strongly respond to biologically relevant metal ions such as calcium(II) and zinc(II), or molecules such as amino acid neurotransmitters. We validated their functionality in various MRI experiments in vitro, ex vivo and in vivo. This presentation will introduce the bioresponsive MRI probes that target essential biomarkers and their potential for use in studying physiological and pathological processes in the brain, including ischemic stroke.