报告摘要：Metallic nanostructures support tightly confined surface plasmon modes that are associated with strongly increased electromagnetic field intensity and local density oif optical states. Such optical resonances are highly attractive in bioanalytical technologies for probing oif chemical and biological species and they frequently serve in plasmonic affinity biosensors as well as in numerous surface enhanced optical spectroscopy methods. Then, the interface oif metallic nanostructures needs to facilitate several key functionalities, particularly efficient capture oif target molecular species, resistance to fouling from other abundant molecules present in the analyzed liquid samples, and their resonances need to be tuned to desired spectral windows. The talk will cover the utilization oif responsive hydrogels in several types oif plasmonic biosensors and for rapid actuating oif plasmonic nanomaterials, including high precision crosslinking and attachment oif an open polymer network structure to the metallic surface by using UV and two-photon absorption process. The employment oif dual optical and responsive hydrogel-based amplification strategies will be discussed in the context oif affinity optical biosensing and in conjunction with additional rolling circle amplification and catalytic hairpin assembly, a route towards facile single molecule detection will be presented.