报告题目：Advanced In Vivo Fluorescence Imaging: Seeing is Believing
报告时间：2017年11月27日 上午 9点
报告时间：2017年11月27日 上午 9点
报告地点：温州生物材料与工程研究所(高新大厦15楼会议室2）
报告人：王强斌博士
报告人简介：
王强斌，博士，中科院“百人计划”研究员，博士生导师，国家杰出青年基金获得者。2002年于华东理工大学获博士学位，2004~2006年在美国亚利桑那州立大学化学与生物化学系从事博士后研究，2006~2008年在美国亚利桑那州立大学生物设计研究院任助理研究教授，2008年7月年加入中科院苏州纳米所，任研究员，课题组长，主要从事纳米晶可控合成、离散纳米结构精确构建、近红外荧光活体影像及其转化医学研究。目前担任中科院苏州纳米所所长助理、中国科学院纳米-生物界面重点实验室主任，中国科学院岗位教授。报告摘要：
Fluorescent imaging in the second near-infrared window (NIR-II, 1.0~1.7 μm) is appealing in in vivo imaging due to minimal autofluorescence and negligible tissue scattering in this region, affording maximal penetration depth for deep tissue imaging with high feature fidelity. Herein, for the first time, we reported a new type of NIR-II QDs-Ag2S QDs and executed a series of in vivo imaging studies by using Ag2S QDs. The results show that, by using Ag2S QDs, the tissue penetration length can reach 1.5 cm, and the spatial and temporal resolution of the in vivo imaging can down to 25 µm and 50 ms, respectively, which are improved several to dozens of times in comparison with those using conventional fluorescence nanoprobes in the visible and the first near-infrared window (650-900 nm), facilitating in situ, real-time visualization of the biological events in vivo. With the advanced NIR-II fluorescence of Ag2S QDs, high signal to noise ratio imaging of tumor growth and angiogenesis, imaging-guided targeting drug-delivery and therapeutics, imaging-guided precision surgery of glioma, and stem cell tracking and regeneration in vivo, etc, have been achieved.
Figure. Characterization of Ag2S QDs and their in vivo real-time visualization of angiogenesis mediated by a subcutaneous xenograft 4T1 mammary tumor.
