课题组简介
  我们的团队由具有不同背景(化学,材料科学,生物学和工程学)的研究人员组成。我们的团队专注于生物应用的蛋白质基水凝胶的开发,包括组织工程,药物筛选和3D生物打印。蛋白质基材料具有出色的生物相容性和生物活性。但是,它们差的机械性能限制了其广泛的生物应用。在这里,我们已经通过甲基丙烯酰化功能化了蛋白质材料,因此它们可以在暴露于光线下固化。光交联赋予了生物制造时空控制以及可定制的机械性能。在光引发剂的存在下,在温和条件下进行光固化,相对地导致良好的生物相容性。基于光固化蛋白的水凝胶已被用于制造高度有序的3D支架/组织类似物,用于3D培养和药物筛选应用。此外,它们已被用于印刷各种组织构造。可光固化的基于蛋白质的水凝胶可以成为多种生物应用的通用材料。
Our team consists of researchers with various backgrounds (chemistry, materials science, biology, and engineering). Our team focuses on the development of protein-based hydrogels for bioapplications including tissue engineering, drug screening, and 3D bioprinting. Protein-based materials exhibit excellent biocompatibility and biological activities. However, their poor mechanical properties limit their wide ranges of bioapplications. Here, we have functionalized protein materials via methacryloylation so that they can be solidified upon exposure to light. Photocrosslinking imparts the spatiotemporal control over biofabrication as well as tailorable mechanical properties. Photocuring is conducted under a mild condition in the presence of a photoinitiator, relatively leading to good biocompatibility. Photocurable protein-based hydrogels have been used to fabricate highly ordered 3D scaffolds/tissue analogues for 3D culture and drug screening applications. Besides, they have been used to print various tissue constructs. Photocurable protein-based hydrogels could become versatile materials for various bioapplications.

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