研究成果
  可光固化的bioinks产品(gelatin methacryloyl(GelMA),Albumin methacryloyl (AlbMA), hyaluronic methacrylate(HAMA),Pluronic diacrylate(Pluronic DA)和 poly(ethylene glycol diacrylate)(PEGDA))是用于生物应用的通用材料,包括3D细胞培养,3D打印,组织工程和组织再生。


Publications

(64 peer-reviewed papers, 3865 citations; H-index: 32)
[64] Jiajun Hu, Kairui Duan, Yueming Zhao, Hangbin Xv, Xinxin Ge, Mian Lin, Hu Zhu, Dingze Chen, Hui Deng*, Bae Hoon Lee*
“Hyperglycemia-responsive nitric oxide-releasing biohybrid cryogels with cascade enzyme catalysis for enhanced healing of infected diabetic wounds”, Journal of Controlled Release, 2025, 378, 912-931. (IF:10.5)
[63] Jiajun Hu#, Yuan Chen, Mian Lin, Kairui Duan, Mengdie Xu, Tingting Li, Yueming Zhao, Bae Hoon Lee*, Hui Deng*,
“Arginine-loaded globular BSAMA/fibrous GelMA biohybrid cryogels with multifunctional features and enhanced healing for soft gingival tissue regeneration”, International Journal of Biological Macromolecules, 2024, 278, 134932.
[62] Hu Zhu, Mian Lin, Yang Li, Kairui Duan, Jiajun Hu, Chunbo Chen, Zhiqiang Yu, Bae Hoon Lee
"LSPR sensing for in situ monitoring the Ag dissolution of Au@ Ag core-shell nanoparticles in biological environments " Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2024, 310, 123885. (IF: 4.831)
[61] Kairui Duan; Nabila Mehwish*; Mengdie Xu; Hu Zhu; Jiajun Hu; Mian Lin; Lu Yu; Bae Hoon Lee* (*corresponding author)
"Autoclavable Albumin-Based Cryogels with Uncompromising Properties" Gels, 2023, 9(9), 712. (5-year IF: 5.2)
[60] Haiyan Yin, Mengxiang Zhu, Yingying  Wang, Lihua Luo, Qingsong Ye*, Bae Hoon Lee* (*corresponding authors)
"Physical properties and cellular responses of gelatin methacryloyl bulk hydrogels and highly ordered porous hydrogels " Frontiers in Soft Matter, 2023, 2, 1101680.
[59] Xiaona Rong, Nabila Mehwis*,  Xueming Niu, Niteng Zhu, Bae Hoon Lee* (*corresponding authors)
"Human albumin-based hydrogels for their potential xeno-free microneedle applications" Macromolecular Bioscience, 2023, 23, 2200463. ( IF:5.859)
[58] Fanhui Kong, Nabila Mehwis*,  Bae Hoon Lee* (*corresponding authors)
"Emerging albumin hydrogels as personalized biomaterials"  Acta Biomaterilaia, 2023, 157, 67-90. ( IF:10.633)  
[57] Nabila Mehwis, Mengdie Xu , Muhammad Zaeem,  Bae Hoon Lee* (*corresponding authors)
"Mussel-Inspired Surface Functionalization of Porous Albumin Cryogels Supporting Synergistic Antibacterial/Antioxidant Activity and Bone-Like Apatite Formation" Gels, 2022, 8 (10), 670. ( 5-year IF: 5.523)
[56] Nabila Mehwish+, Yuan Chen+, Muhammad Zaeem, Yi Wang, Bae Hoon Lee*, Hui Deng* (+first authors,*corresponding authors)
"Novel biohybrid spongy scaffolds for fabrication of suturable intraoral graft substitutes" International Journal of Biological Macromolecules, 2022, 214, 617. (IF: 8.025)
[55] Xueming Niu, Mian Lin, and Bae Hoon Lee* (*corresponding author)
"An Engineered Protein-Based Building Block (Albumin Methacryloyl) for Fabrication of a 3D In Vitro Cryogel Model" Gels, 2022, 8(7), 404. (5-year IF: 5.523)
[54] Mengdie Xu+, Nabila Mehwish+, Bae Hoon Lee* ((+ first authors, *corresponding author)
"Facile Fabrication of Transparent and Opaque Albumin Methacryloyl Gels with Highly Improved Mechanical Properties and Controlled Pore Structures" Gels, 2022, 8(6), 367. (5-year IF: 5.523)
[53] Yuan Chen+, Meng Jiao Zhai+`, Nabila Mehwish, Meng Die Xu, Yi Wang, Yi Xuan Gong, Man Man Ren, Hui Deng*, Bae Hoon Lee* (*corresponding authors)
"Comparison of globular albumin methacryloyl and random-coil gelatin methacryloyl: Preparation, hydrogel properties, cell behaviors, and mineralization" International Journal of Biological Macromolecules, 2022, 204, 692. (IF: 8.025)
[52] Fanhui Kong, Nabila Mehwish, Xueming Niu, Minzhao Lin, Xiona Rong, Fangbin Hu, and Bae Hoon Lee* (*corresponding author)
“Personalized hydrogels for individual health care: Preparation, features, and applications in tissue engineering” Materials Today Chemistry, 2021, 22, 100612. (IF: 7.613)
[51] Xueming Niu, Shuqian Wan, Xiona Rong, Mian Lin, Nabila Mehwish, Kun Wei* and Bae Hoon Lee* (*corresponding authors)
“Facile Fabrication of Povidone Iodine‐Embedded Polytetrafluoroethylene Superhydrophobic Films with Improved Antiadhesive and Bactericidal Properties in Bacterial Environments” Macromolecular Materials and Engineering, 2021, 167, 479-490. (IF: 4.402)
[50] TarunAgarwal, Dishary Banerjee, Rocktotpal Konwarh, Timothy Esworthy, Jyoti Kumari, Valentina Onesto, Prativa Das, Bae Hoon Lee, Frank A.D.T.G. Wagener, Pooyan Makvandi, Virgilio Mattoli, Sudip Kumar Ghosh, Tapas Kumar Maiti, Lijie Grace Zhang, Ibrahim T.Ozbolat
“Recent Advances in Bioprinting Technologies for Engineering Hepatic Tissue” Materials Science and Engineering: C, 2021, 123, 112013. (IF: 8.457)
[49] Chenyuan Gao, Wan Ting Sow, Yingying Wang, Yili Wang, Dejun Yang, Bae Hoon Lee, Dražen Matičić, Lian Fang, Huaqiong Li* and Chunwu Zhang*
“Hydrogel composite scaffold with attenuated immunogenicity component for bone tissue engineering application” Journal of Materials Chemistry B, 2021, 9, 2033-2041. (IF: 7.571) 10.1088/1758-5090/abd157
[48] Ajay Tijore, Bae Hoon Lee, Lay Poh Tan*
“Bioactive micropatterned platform to engineer myotube-like cells from stem cells” Biofabrication, 2021, 13, 035017. (IF: 11.061)
[47] Xueming Niu, Gaia Ferracci, Mian Lin, Xiona Rong, Mengxiang Zhu, Nam-Joon Cho* and Bae Hoon Lee* (*corresponding authors)
“Highly substituted decoupled gelatin methacrylamide free of hydrolabile methacrylate impurities: An optimum choice for long-term stability and cytocompatibility” International Journal of Biological Macromolecules, 2021, 167, 479-490. (IF: 8.025)
[46] Dattatrya Shetti and Bae Hoon Lee*
“Pristane-induced mammary carcinomas” Methods in Cell Biology, 2021, 163, 187-195. (IF: 1.829)
[45] Ye Cao, Bae Hoon Lee, Scott Alexander Irvine, Yee Shan Wong, Havazelt Bianco Peled*, and Subramanian Venkatraman*
“Inclusion of CrossLinked Elastin in Gelatin/PEG Hydrogels Favourably Influences Fibroblast Phenotype” Polymers, 2020, 12, 670. (IF: 4.967)
[44] Gaia Ferracci, Mengixang Zhu, Mohammed Shahrudin Ibrahim, Gamaliel Ma, Teng Fei Fan, Bae Hoon Lee*, and Nam-Joon Cho* (*corresponding authors)
“Photocurable Albumin Methacryloyl Hydrogels as a Versatile Platform for Tissue Engineering” ACS Applied Bio Materials, 2020, 3, 920-934.
[43] Dattatrya Shetti, Bao Zhang, Conghui Fan, Canlong Mo, Bae Hoon Lee*, and Kun Wei* (*corresponding authors)
“Low dose of Paclitaxel Combined with XAV939 Attenuates Metastasis, Angiogenesis, and Growth in Breast Cancer by Suppressing Wnt Signaling” cells (MDPI), 2019, 8, 892. (IF:7.666)
[42] Fanhui Kong+, Conghui Fan, Yulian Yang, Bae Hoon Lee*+, and Kun Wei* (*corresponding and +first authors)
“5-hydroxymethylfurfural-embedded poly (vinyl alcohol)/sodium alginate hybrid hydrogels accelerate wound healing” International Journal of Biological Macromolecules, 2019, 138, 933. (IF: 8.025)
[41] Mintu Pal, Huizhi Chen, Bae Hoon Lee, Yun Sheng Yip, Nguan Soon Tan*, Lay Poh Tan*
“Epithelial-mesenchymal transition of cancer cells using bioengineered hybrid scaffold composed of hydrogel/3D-fibrous framework” Scientific Reports, 2019 9:6863. (IF: 4.996)
[40] MengXiang Zhu, Yingying Wang, Gaia Ferracci, Jing Zheng, Nam-Joon Cho*, Bae Hoon Lee* (*corresponding authors)
“Gelatin methacryloyl with a high degree of controllability and batch-to-batch consistency for hydrogel fabrication” Scientific Reports, 2019, 9, 6863. (IF: 4.996, 144 citations)
[39] Miaomiao Zhou, Bae Hoon Lee*, Yu Jun Tan, Lay Poh Tan* (*corresponding authors)
“Microbial Transglutaminase Induced Controlled Crosslinking of Gelatin Methacryloyl to Tailor Rheological Properties for 3D Printing” Biofabrication, 2019, 11, 025011. (IF: 11.061)
[38] Fanhui Kong, Xueming Niu, Bae Hoon Lee*, Kun Wei* (*corresponding authors)
“5-Hydroxymethylfurfural mitigates lipopolysaccharide-stimulated inflammation via suppression of MAPK, NF-κB, and mTOR activation in RAW 264.7 cells” Molecules, 2019, 24, 275. (IF: 4.927)
[37] Jing Zheng, MengXiang Zhu, Gaia Ferracci, Nam-Joon Cho*, Bae Hoon Lee*
“Hydrolytic stability of methacrylamide and methacrylate in gelatin methacryloyl (GelMA) and decoupling of gelatin methacrylamide from GelMA through hydrolysis” Macromolecular Chemistry and Physics, 2018, 219, 1800266. (DOI: 10.1002/macp.201800266) (IF: 2.996)
[36] Xiaoyan Wang, Brian Key, Bae Hoon Lee, Huaqiong Li*, Qingsong Ye*
“Potential Roles of Dental Pulp Stem Cells in Neural Regeneration and Repair” Stem Cells International, 2018, ID 1731289, 15 pages. (IF: 5.443, 107 citations)
[35] Wei Shan Lim+, Kenneth Chen+, Tsung Wen Chong, Gordon Minru Xiong, William R Birch, Jisheng Pan, Bae Hoon Lee, Pei Shan Er, Abhijit Vijay Salvekar, Subbu S Venkatraman*, Yingying Huang*
“A bilayer swellable drug-eluting ureteric stent: Localized drug delivery to treat urothelial diseases” Biomaterials, 2018, 165, 25-38. (IF: 15.304)
[34] Miaomiao Zhou+, Bae Hoon Lee+, Lay Poh Tan* (+first authors)
“A dual crosslinking strategy to tailor rheological properties of gelatin methacryloyl” International Journal of Bioprinting, 2017, 3(2), 130. (IF: 7.422)
[33] Bae Hoon Lee+, Hitomi Shirahama+, Myung Hee Kim+, Jae Ho Lee, Lay Poh Tan*, Nam Joon Cho* (+first authors)
“Colloidal Templating of Highly Ordered Gelatin Methacryloyl-Based Hydrogel Platforms for Three-Dimensional Tissue Analogues” NPG Asia Materials, 2017, 9, e412. (IF: 10.761)
[32] Bae Hoon Lee+*, Nathaniel Lum+, Li Yuan Seow+, Pei Qi Lim, Lay Poh Tan* (+first authors, *corresponding authors)
“Synthesis and Characterization of Types A and B Gelatin Methacryloyl for Bioink Applications” Materials, 2016, 9(10), 797. (IF: 3.74, 119 citations)
[31] Hitomi Shirahama+, Bae Hoon Lee+, Lay Poh Tan*, Nam Joon Cho* (+first authors)
“Precise Tuning of Facile One-pot Gelatin Methacryloyl(GelMA) Hydrogel Synthesis” Scientific Reports, 2016, 6, 31036. (IF: 4.996, 204 citations)
[30] Cao Ye, Bae Hoon Lee, Havazelet Bianco-Peled*, Subbu S Venkatraman*
“Synthesis of stiffness-tunable and cell-responsive gelatin-Poly (ethylene glycol) hydrogel for 3-dimensional cell encapsulation” Journal of Biomedical Materials Research Part A, 2016, DOI: 10.1002/jbm.a.35779. (IF: 4.854)
[29] Bae Hoon Lee+, Hitomi Shirahama+, Nam Joon Cho*, Lay Poh Tan* (+first authors)
“Efficient and controllable synthesis of highly substituted gelatin-methacrylamide for mechanically stiff hydrogels” RSC Adv., 2015, 5, 106094-106097. (IF: 4.036)
[28] Animesh Agrawal+, Bae Hoon Lee+, Scott A. Irvine, Jia An, Ramya Bhuthalingam, Vaishali Singh, Kok Yao Low, Chee. Kai. Chua, and Subbu S. Venkatraman* (+first authors)
“Smooth muscle cell alignment and phenotype control by meltspun polycaprolactone (PCL) fibers for seeding of tissue engineered blood vessels.” International Journal of Biomaterials 2015 (4), Article ID434876, 8 pages. (IF: 3.39)
[27] Bae Hoon Lee, Myung Hee Kim, Jae Ho Lee, Dror Seliktar, Nam Joon Cho*, Lay Poh Tan*
“Modulation of Huh 7.5 Spheroid Formation and Functionality using Modified PEG-based Hydrogels of Different Stiffness” PLoS ONE, 2015, 10(2): e0118123. (IF: 3.752)
[26] Scott A. Irvine, Animesh Agrawal, Bae Hoon Lee, Huiyee Chua, Kok Yao Low, Marcelle Machluf, Subbu Venkatraman*
“Printing cell-laden gelatin constructs by free-form fabrication and enzymatic protein crosslinking” Biomedical Microdevices, 2015, 17(1), 9915. (IF: 3.783, 111 citations)
[25] Bae Hoon Lee, Stella Poh Hui Tin, Yun Xia, Terry W.J. Steele, Dror Seliktar, Havazelet Bianco-Peled*, Subbu S Venkatraman*
“The influence of soluble PEG incorporation in a PEG-fibrinogen (PF) hydrogel on smooth muscle cell morphology and growth in 3-D encapsulation and culture” Journal of Biomaterials Science, polymer edition, 2014, 25, 394-409. (IF: 3.682)
[24] Bae Hoon Lee, Hanin H. Bearat, Vicki Cheng, Ryan McLemore, Stephanie A. Robb, Zhanwu Cui, Allan Dovigi, Brent L. Vernon*
"In vitro and In vivo demonstration of physically and chemically in situ gelling NIPAAm-based copolymer system” Journal of Biomaterials Science, polymer edition, 2013, 24, 1575-1588. (IF: 3.682)
[23] Hanin H. Bearat, Bae Hoon Lee, Brent L. Vernon*
“Comparison of properties between NIPAAm-based simultaneously physically and chemically gelling polymer systems for use in vivo” Acta biomaterialia, 2012, 8, 3629-42. (IF: 10.633)
[22] Zhanwu Cui, Bae Hoon Lee, Christian Pauken, Brent Vernon*
“Degradation, cytotoxicity and biocompatibility of NIPAAm-based thermosensitive, injectable and bioresorbable polymer hydrogels” Journal of Biomedical Materials Research Part A, 2011, 98A, 159-166. (IF: 4.854)
[21] Hanin H. Bearat, Bae Hoon Lee, Jorge Valdez, Brent L. Vernon*
"Synthesis, Characterization and Properties of a Physically and Chemically Gelling Polymer System Using Poly(NIPAAm-co-HEMA-acrylate) and Poly(NIPAAm-co-cysteamine)." Journal of Biomaterials Science, polymer edition, 2011, 22, 1299-1318. (IF: 3.682)
[20] Bae Hoon Lee, Christine Leon, Ryan McLemore, Jorge Valdez Macias, Brent L. Vernon
"Synthesis and characterization of Thermo-sensitive radio-opaque Poly(N-isopropylacrylamide-co-PEG-2-iodobenzoate)” Journal of Biomaterials Science, polymer edition, 2011, 22, 2357-2367. (IF: 3.682)
[19] Bae Hoon Lee, Soo-chang Song*
“Synthesis and Characterization of Thermosensitive Poly(organophosphazene) Gels with an Amino Functional Group " Journal of Applied Polymer Science, 2011, 120, 998-1005. (IF: 3.057)
[18] Brandon Blakely, Bae Hoon Lee, Celeste Riley, Ryan McLemore, Brent Vernon*
“Formulation and Characterization of Radio-opaque Conjugated In Situ Gelling Materials” Journal of Biomedical Materials Research: Part B, Applied Biomaterials, 2010, 93B, 9-17. (IF: 3.405)
[17] Ryan McLemore, Stephanie Robb, Bae Hoon Lee, Caplan Michael, Brent Vernon*
“Michael-Type addition reactions in NIPAAm-cysteamine copolymers follow Second Order Rate Laws with Steric Hindrance” Annals of Biomedical Engineering, 2009, 37, 2416-2425. (IF: 4.219)
[16] Eric Henderson, Bae Hoon Lee, Zhanwu Cui, Ryan McLemore, Ted Brandon, Brent Vernon*
“In vivo evaluation of temperature-sensitive polymer with time dependent LCST” Journal of Biomedical Materials Research Part A, 2009, 90A, 1186-1197. (IF: 4.854)
[15] Christine Leon, Bae Hoon Lee, Preul M, Ryan McLemore, Brent Vernon*
“Synthesis and characterization of radio-opaque thermosensitive poly [N-isopropylacrylamide-2,2-(ethylenedioxy)bis(ethylamine)-2,3,5-triiodobenzamide]” Polymer international, 2009, 58, 847-850. (IF: 3.213)
[14] Eric Henderson, Bae Hoon Lee, Zhanwu Cui, Ryan McLemore, Ted Brandon, Brent Vernon*
“In vivo evaluation of temperature-sensitive polymer with time dependent LCST” Journal of Biomedical Materials Research Part A, 2009, 90A, 1186-1197. (IF: 4.854)
[13] Ryan McLemore, Bae Hoon Lee, Brent Vernon*
“Surfactant effects on the kinetics of Michael-type addition reaction in reverse emulsion polymeric systems.” Journal of Biomedical Materials Research Part B, 2009, 89, 191-198. (IF: 3.405)
[12] Stephanie Robb, Bae Hoon Lee, Ryan McLemore, and Brent Vernon*
“Simultaneously Physically and Chemically Gelling Polymer System utilizing a poly(NIPAAm-co-Cysteamine) Based Copolymer.” Biomacromolecules, 2007, 8, 2294-2300. (IF: 6.978)
[11] Vicki Cheng, Bae Hoon Lee, Christine Pauken, and Brent Vernon*
“Poly(N-isopropylacrylamide-co-Poly(ethylene glycol))-Acrylate Simultaneously Physically and Chemically Gelling Polymer Systems " Journal of Applied Polymer Science, 2007, 106, 1201-1207. (IF: 3.057)
[10] Zhanwu Cui , Bae Hoon Lee, and Brent Vernon*
“A New Hydrolysis-dependent Thermosensitive Polymer for Injectable, Degradable System " Biomacromolecules, 2007, 8, 1280-1286. (IF: 6.978)
[9] Bae Hoon Lee, Bianca West, Ryan McLemore, Christine Pauken, and Brent Vernon*
"An In situ Injectable Physically and Chemically Gelling NIPAAm-based Copolymer system for embolization " Biomacromolecules, 2006, 7, 2059. (IF: 6.978, 130 citations)
[8] Bae Hoon Lee, and Brent Vernon*
"In-situ gelling erodible N-isopropylacrylamide copolymers" Macromolecular Biosciences, 2005, 5, 629. (IF: 5.859)
[7] Bae Hoon Lee, and Brent Vernon*
"Copolymers of N-isopropylacrylamide, HEMA-lactate, and acrylic acid with time-dependent LCST for a bioresorbable carrier " Polymer International, 2005, 54, 418. (IF: 3.213)
[6] Bae Hoon Lee, and Soo-chang Song*
"Synthesis and Characterization of Biodegradable Thermosensitive Poly(organophosphazene) Gels" Macromolecules, 2004, 37, 4533. (IF: 6.057, 123 citations)
[5] Bae Hoon Lee, Jeong-soo Park, Soo-chang Song*
"Synthesis and Biocompatibility of Thermosensitive Poly(organophosphazene) Gels" Biomaterials Research, 2003, 7, 182. (Korea)
[4] Soo-chang Song, Sang Beom Lee, Bae Hoon Lee, Hyung-Wook Ha, Kyung-Tae Lee, and Youn Soo Sohn*
"Synthesis and antitumor activity of novel thermosensitive platinum (II)-cyclotriphosphazene conjuagtes" J. Controlled Release, 2003, 90, 303. (IF: 11.467)
[3] Bae Hoon Lee, Young Moo Lee, Youn Soo Sohn, and Soo-chang Song*
"Synthesis and Characterization of Thermosensitive Poly(organophosphazenes) with Methoy-Poly(ethylene glycol) and Alkylamines as side groups" Bull. Korean Chem. Soc, 2002, 23, 549. (IF: 0.787)
[2] Bae Hoon Lee, Young Moo Lee, Youn Soo Sohn, and Soo-chang Song*
"Thermosensitive and Hydrolysis-sensitive poly(organophosphazenes)" Polymer International, 2002, 51, 658. (IF: 3.213)
[1] Bae Hoon Lee, Young Moo Lee, Youn Soo Sohn, and Soo-chang Song*
"A Thermosensitive Poly(organophosphazene) Gel" Macromolecules, 2002, 35, 3876. (IF: 6.057, 194 citations)

Book Chapters

[1] Bae Hoon Lee*, Ajay Tijore, C. R. I. Lam, Hui Chen, K. M. Kumar, and Lay Poh tan* “Engineering Stem Cell Niche and Stem Cell–Material Interactions” Smart Materials for Tissue Engineering: Fundamental Principles, Chapter: Engineering Stem Cell Niche and Stem Cell–Material Interactions, Publisher: Royal Society of Chemistry, Editors: Qun Wang, 2016, pp.163-196. DOI: 10.1039/9781782626756-00163 (December 13, 2016).
[2] Hitomi Shirahama and Bae Hoon Lee* “Hydrogels: Design, Synthesis and Application in Drug Delivery and Regenerative Medicine”, Chapter 15: Preparation of Photocurable Hydrogels, Publisher: CRC Pres, Editors: Thakur Raghu Raj Singh, Garry Laverty, Ryan Donnelly, 2018, pp.265-283. ISBN 9781498748612 (February 28, 2018).

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