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Our Journal of Controlled Release paper published online
Our Journal of Controlled Release paper published online
Published On: 2023-01-16
We are pleased to announce our newest paper in Journal of Controlled Release is now published online.
Abstract
Bacterial biofilms, especially ones caused by multi-drug resistant strains, are increasingly posing a significant threat to human health. Inspired by nature, we report the fabrication of glucose oxidase-loaded iron-phenolic networks that can power the cascade reaction to generate free radicals to eradicate bacterial biofilms. A soft template, glucose oxidase activity during encapsulation, yielding the porous nanocomplexes after removing the template. The porous nature of nanocomplexes, characterized via transmission electron microscopy, N2thermogravimetric analysis, facilitates the diffusion of substrates and products during the cascade reaction and protects protease attack. Our optimized nanocomplexes (Fe-GA/GOx) could efficiently kill drug-resistant ESKAPE pathogens, including the clinically isolated strains and eradicate their biofilms. In this regard, Fe-GA/GOx could induce over 90% of the biomass of Staphylococcus aureus biofilms. In the murine Staphylococcus aureus and pneumonia model induced by Klebsiella pneumoniae, our Fe-GA/GOx nanocomplexes could efficiently eradicate the bacteria (over 3-log reduction in colony-forming units) and alleviate the inflammatory response without notable side effects on normal tissues. Therefore, our strategy may provide an efficient alternative treatment to combat bacterial biofilms and address the emergence of drug resistance.<a class="topic-link" data-cke-saved-href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/peritonitis" href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/peritonitis" title="Learn more about peritonitis from ScienceDirect" s="" ai-generated="" topic="" pages"="" style="box-sizing: border-box; padding: 0px; margin: 0px; text-decoration-line: none; text-decoration-thickness: 1px; text-decoration-color: rgb(46, 46, 46); list-style: none; color: rgb(46, 46, 46); background-color: transparent; word-break: break-word; text-underline-offset: 1px;">
