YANG Gen's Research Group
Group Name
YangLab group: Cancer Screening & Theranostics
Principal Investigator
Dr. Gen Yang, Professor of School of Physics, Peking University; Professor of the Center of biomedical Physics, Wenzhou Institute, University of Chinese Academy of Sciences. Dr. Yang is currently serving as a review expert at the Degree Center of the Ministry of Education of the People's Republic of China, a review expert of the National Natural Science Foundation of China/ Beijing Natural Science Foundation/Hong Kong Science Foundation, a member of the Professional Committee and Youth Committee of the Beam Technology Branch of the Chinese Nuclear Society (CNS). His research focuses on the early diagnostics and therapy of cancer from basic research to clinical practice. He has published over 30 papers in peer-reviewed international journals. At present, he is undertaking seven scientific/clinical related research fundings.
Research Area
Our team focuses on the early diagnostics and therapy of cancer from basic research to clinical practice. One research theme is the development of generalized, cost-effective and high-accuracy innovative platforms with notable clinical application potential for early cancer diagnostics. The platforms are established through the multi-disciplinary integration of biology, physics, nanotechnology as well as microfluidics, and empower the deeply comprehensive profiling of cancer biomarkers in biological targets (e.g., CTC, ctDNA, extracellular vesicles). Another research theme is establishing novel cancer therapy strategies and precision medicine screening systems through integrating tumor immunology, physics, and radiology with other technologies such as organoid and automatic micro/nano fabrication. Our current team is highly diverse and the team expertise spans the field of microfluidic device, radiation therapy, nanomaterials science, extracellular vesicles, CTC and biosensor. Our team has applied a series of patents and published research articles in prestigious journals including Nature Communications, Matter, Lab on Chip, Chemical Engineering Journal.
Representative Publications
- Zhigang Wang, Huilin Shao* et al., Surfactant-guided spatial assembly of nano-architectures for molecular profiling of extracellular vesicles. Nature Communications, 12: 4039, 2021.
- Jintao Han, Gen Yang* et al., Ultra-High Dose Rate FLASH Irradiation Induced Radio-Resistance of Normal Fibroblast Cells Can Be Enhanced by Hypoxia and Mitochondrial Dysfunction Resulting From Loss of Cytochrome C. Frontiers in Cell and Developmental Biology 9: 672929, 2021.
- Chunyang Lu, Gen Yang* et al., Electrochemical Detection and Point-of-Care Testing for Circulating Tumor Cells: Current Techniques and Future Potentials. Sensors 20(21): 6073, 2020.
- Zhenzhen Xu, Changqing Yi* et al., A smartphone-based quantitative point-of-care testing (POCT) system for simultaneous detection of multiple heavy metal ions. Chemical Engineering Journal 394:124966, 2020.
- Chunyang Lu, Gen Yang* et al., A novel microfluidic device integrating focus-separation speed reduction design and trap arrays for high-throughput capture of circulating tumor cells. Lab on Chip 20: 4094-4105, 2020 (Cover).
- Xudong Wang, Gen Yang* et al., Cancer stem-like cells with hybrid epithelial/mesenchymal phenotype leading the collective invasion. Cancer Science 111: 467-476, 2020 (Cover).
- Wenzong Ma, Gen Yang* et al., Mixed secondary chromatin structure revealed by modeling radiation-induced DNA fragment length distribution. Science China Life Sciences, 63: 825-834, 2020.